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Synthesis and Evaluation of No-Carrier-Added 8-Cyclopentyl-3-(3-[ 18 F]fluoropropyl)-1-propylxanthine ([ 18 F]CPFPX): A Potent and Selective A 1 -Adenosine Receptor Antagonist for in Vivo Imaging

✍ Scribed by Holschbach, Marcus H.; Olsson, Ray A.; Bier, Dirk; Wutz, Walter; Sihver, Wiebke; Schüller, Manfred; Palm, Bettina; Coenen, Heinz H.


Book ID
126906985
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
137 KB
Volume
45
Category
Article
ISSN
0022-2623

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✍ Marcus H. Holschbach; Walter Wutz; Manfred Schüller; Dirk Bier; H.H. Coenen 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 97 KB

The reduction of 1-allyl-8-cyclopentyl-3-(3-fluoropropyl)xanthine, 7, with tritium gas catalyzed by 10% Pd-C gave 8-cyclopentyl-3-(3-fluoropropyl)-1-[2,3-3 H]propylxanthine ([ 3 H]CPFPX), 8\*, a potent and selective antagonist for the A 1 adenosine receptor (A 1 AR). The synthesis of 7 proceeded fro