Tritium-labelled 8-cyclopentyl-3-(3-fluo
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Marcus H. Holschbach; Walter Wutz; Manfred Schüller; Dirk Bier; H.H. Coenen
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Article
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2003
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John Wiley and Sons
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French
⚖ 97 KB
The reduction of 1-allyl-8-cyclopentyl-3-(3-fluoropropyl)xanthine, 7, with tritium gas catalyzed by 10% Pd-C gave 8-cyclopentyl-3-(3-fluoropropyl)-1-[2,3-3 H]propylxanthine ([ 3 H]CPFPX), 8\*, a potent and selective antagonist for the A 1 adenosine receptor (A 1 AR). The synthesis of 7 proceeded fro