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Synthesis and Evaluation of N-(5-Methyl-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazol-4-yl) -N′-phenylureas as Cholecystokinin Antagonists.

✍ Scribed by Eric Lattmann; Jintana Sattayasai; Yodchai Boonprakob; Pornthip Lattmann; Harjit Singh


Publisher
John Wiley and Sons
Year
2005
Weight
19 KB
Volume
36
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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✍ Alessandro Stella; Kenneth Segers; Steven De Jonghe; Bart Vanderhoydonck; Jef Ro 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 206 KB 👁 2 views

The 2-(1,2-dihydro-3-oxo-3H-pyrazol-2-yl)benzothiazole scaffold was selected as a central core structure for the discovery of novel antibacterial compounds. A systematic variation of the substituents on the oxo-pyrazole moiety, as well as on the benzo moiety, led to the creation of a small and focus