Synthesis and evaluation of heparin immobilized “side-on” to polystyrene microspheres coated with end-group activated polyethylene oxide

Synthesis and anticoagulant activity of

Synthesis and anticoagulant activity of heparin immobilized “end-on” to polystyrene microspheres coated with end-group activated polyethylene oxide

✍ Allyson K. Fry; Karl F. Schilke; Joseph McGuire; Karyn E. Bird 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 448 KB

## Abstract Thiol groups were introduced to unfractionated heparin (UFH) and end‐aminated heparin (HepNH~2~) by reaction with 2‐iminothiolane under conditions favoring selective modification of terminal over primary amines. End‐thiolated heparin retained anticoagulant activity as shown by the activ