A series of selenophene derivatives 3 were synthesized as potential CHK1 inhibitors. The effects of substitution on the 4'- or 5'-position of selenophene moiety and shifting the hydroxyl group position on C6- phenolic ring of oxindole were explored. This study led to the discovery of the most potent
Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors
β Scribed by Rahman Shah Zaib Saleem; Theresa A. Lansdell; Jetze J. Tepe
- Book ID
- 118249918
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 530 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0968-0896
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
The racemic 2-azabicyclo[3.2.2]nonanes 5 and 18 were synthesized and tested as b-glycosidase inhibitors. The intramolecular Diels-Alder reaction of the masked o-benzoquinone generated from 2-(allyloxy)phenol ( 6) gave the a-keto acetal 7 which was reduced with SmI 2 to the hydroxy ketone 8. Dihydrox