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Synthesis and evaluation of antitumor activity of a homologous series of 1-(ω-cyanoalkyl)-and 1,3-bis (ω-cyanoalkyl)uracil nucleoside analogues

✍ Scribed by Jack C. Kim; Eun-Soo Dong; Jun-Won Ahn; Seon-Hee Kim

Book ID
112960163
Publisher
Springer
Year
1994
Tongue
English
Weight
307 KB
Volume
17
Category
Article
ISSN
0253-6269

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## Abstract magnified image Reaction of 1,3‐phenylenediacetonitrile with the zinc organometallic reagent of ethyl 2‐bromobutyrate afforded the 1,3‐phenylene‐bis(acetoacetate) **2** which was used as the starting material for the synthesis of 1,3‐phenylene‐bis[6‐(2‐thiouracil)] **4**. Desulphurizat