Synthesis and evaluation of a series of aryl[e]fused pyrazolo[4,3-c]pyridines with potential anxiolytic activity
β Scribed by Forbes, Ian T.; Johnson, Christopher N.; Jones, Graham E.; Loudon, Julia; Nicholass, Jane M.; Thompson, Mervyn; Upton, Neil
- Book ID
- 120709271
- Publisher
- American Chemical Society
- Year
- 1990
- Tongue
- English
- Weight
- 733 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0022-2623
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## Abstract **A privileged structure**: A library of tetrahydroβ1,4βpyrazoloβdiazepinβ8(2__H__)βones was designed and synthesized to probe the privileged nature of the scaffold. The design strategy included mimicking the threeβdimensional conformations of Ξ²βturn peptides. Screening against P2X~7~R,