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Synthesis and evaluation of a novel bleomycin A2 analogue: continuing assessment of the linker domain

✍ Scribed by Dale L Boger; Brian M Aquila; Winston C Tse; Mark Searcey

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
743 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis and evaluation of a bithiazole ester analogue of deglycobleomycin A 2 that addresses the importance of the bithiazole-L-threonine amide for efficient DNA cleavage is described.

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The efficient preparation of a novel analogue of the BCD oligosaccharide domain of Calicheamicin y~x is described in which the thioester linkage found in the natural product is replaced by an ester group.