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Synthesis and evaluation of a library of peptidomimetics based upon the β-turn

✍ Scribed by Alex A. Virgilio; Andrew A. Bray; Wei Zhang; Lon Trinh; Michael Snyder; Michael M. Morrissey; Jonathan A. Ellman

Book ID
108374665
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
741 KB
Volume
53
Category
Article
ISSN
0040-4020

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✍ John H Grimes Jr.; Yvonne M Angell; Wayne D Kohn 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 116 KB

The solid-phase synthesis of a dipeptide derived 2-amino-3-oxohexahydroindolizino[8,7-b]indole-5-carboxylate system (IBTM) is described. The IBTM moiety is formed via a solid-phase mediated Pictet-Spengler reaction of N-terminal tryptophan and the 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-me