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Synthesis and evaluation of a C-6 alkylated pyrimidine derivative for the in vivo imaging of HSV1-TK gene expression

✍ Scribed by Ursina Müller; Miljen Martić; Tatjana Gazivoda Kraljević; Svjetlana Krištafor; Tobias L. Ross; Charlene Ranadheera; Adrienne Müller; Mariana Born; Stefanie D. Krämer; Silvana Raić-Malić; Simon M. Ametamey

Book ID
116799786
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
580 KB
Volume
39
Category
Article
ISSN
0969-8051

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

The synthesis of a new probe for PET ima
The synthesis of a new probe for PET imaging reporter gene HSV1-tk: 2-amino-6-[18F] fluoro-9- (4-hydroxy-3-hydroxymethylbutyl) purine (6-[18F]fluoropenciclovir)
✍ Hancheng Cai; Duanzhi Yin; Lan Zhang; Yongxian Wang 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 199 KB

The one step radiosynthesis of 2-amino-6-[ 18 F]fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-[ 18 F]fluoropenciclovir) 6 is reported. Radiolabeled product 6-[ 18 F]fluoropenciclovir 6 was prepared by radiofluorination of compound 4 with [ 18 F]KF and isolated by a silica Sep-Pak cartridge. Th