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Synthesis and evaluation of a 99mTc-MAMA-propyl-thymidine complex as a potential probe for in vivo visualization of tumor cell proliferation with SPECT

✍ Scribed by Sofie Celen; Tjibbe de Groot; Jan Balzarini; Kathleen Vunckx; Christelle Terwinghe; Peter Vermaelen; Lizette Van Berckelaer; Hubert Vanbilloen; Johan Nuyts; Luc Mortelmans; Alfons Verbruggen; Guy Bormans

Book ID: 116799076
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 445 KB
Volume: 34
Category: Article
ISSN: 0969-8051
DOI: 10.1016/j.nucmedbio.2007.01.003

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✍ Kristof Prinsen; Lixin Jin; Kathleen Vunckx; Marijke De Saint-Hubert; Lin Zhou; 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 581 KB

N,N'-bis(diethylenetriamine pentaacetic acid)-3,3'-(benzylidene)-bis-(1H-indole-2-carbohydrazide) (bis-DTPA-BI) was radiolabeled with (99m)Tc(CO)(3). The resulting (99m)Tc(CO)(3)-bis-DTPA-BI was characterized (LC-MS) and evaluated as a potential SPECT tracer for imaging of necrosis in Wistar rats wi