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Synthesis and evaluation of 2,4-diaminoquinazoline antifolates with activity against methotrexate-resistant human tumor cells

✍ Scribed by Jan H. Schornagel; Pauline K. Chang; Louis J. Sciarini; Barbara A. Moroson; Enrico Mini; Arlene R. Cashmore; Joseph R. Bertino

Book ID: 115777388
Publisher: Elsevier Science
Year: 1984
Tongue: English
Weight: 534 KB
Volume: 33
Category: Article
ISSN: 0006-2952
DOI: 10.1016/0006-2952(84)90086-8

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## Abstract Deoxyharringtonine (**2**), homoharringtonine (**3**), homodeoxyharringtonine (**4**), and anhydroharringtonine (**5**) are reported to be among the most potent members of the antileukemia alkaloids isolated from the __Cephalotaxus__ genus. Convergent syntheses of these four natural pro