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Synthesis and evaluation of 2-anilinopyrimidines bearing 3-aminopropamides as potential epidermal growth factor receptor inhibitors

✍ Scribed by Han, Chun; Wan, Ledong; Ji, Hongbin; Ding, Ke; Huang, Zhangjian; Lai, Yisheng; Peng, Sixun; Zhang, Yihua

Book ID: 122302950
Publisher: Elsevier Science
Year: 2014
Tongue: French
Weight: 929 KB
Volume: 77
Category: Article
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2014.02.032

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## Abstract With the aim of developing inhibitors of EGFR tyrosine kinase, the 7‐methoxymethyl‐[1, 4]dioxano[2, 3‐__g__]quinazolines (**3a—b**) and 7‐mono‐ or di‐alkylaminomethyl‐[1, 4]dioxano[2, 3‐__g__]quinazolines (**4a—i**) were prepared and evaluated for the inhibition of EGFR tyrosine kinase