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Synthesis and evaluation of 2-(3′-lodo-4′-aminophenyl)-6-hydroxybenzothiazole for in vivo quantitation of amyloid deposits in alzheimer’s disease

✍ Scribed by Yanming Wang; William E. Klunk; Guo-Feng Huang; Manik L. Debnath; Daniel P. Holt; Chester A. Mathis


Book ID
107574879
Publisher
Humana Press Inc
Year
2002
Tongue
English
Weight
134 KB
Volume
19
Category
Article
ISSN
0895-8696

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## Abstract 4‐Fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)piperazin‐1‐yl]ethyl}benzamide is a full 5‐HT~1A~ agonist with high affinity (__pK__~__i__~=9.3), selectivity and a __c__ log __P__ of 3.045. The corresponding PET radioligand 4‐[^18^F]fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)