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Synthesis and Evaluation of 1,2,3-Triazole Containing Analogues of the Immunostimulant α-GalCer

✍ Scribed by Lee, Taeho; Cho, Minjae; Ko, Sung-Youl; Youn, Hyun-Jun; Baek, Dong Jae; Cho, Won-Jea; Kang, Chang-Yuil; Kim, Sanghee

Book ID
126097881
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
140 KB
Volume
50
Category
Article
ISSN
0022-2623

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Synthesis of 1,2,3-Triazole Analogues of
Synthesis of 1,2,3-Triazole Analogues of Lincomycin
✍ Marie-Pierre Collin; Sven N. Hobbie; Erik C. Böttger; Andrea Vasella 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 German ⚖ 242 KB

## Abstract In search for new antibiotics we replaced the amide moiety of lincomycin **1** by a 1,2,3‐triazole ring. The 1,2,3‐triazoles **10a**–**10k** were obtained as single regioisomers by ‘click reaction’ of azide **5** with the alkyne **9k**, derived from propyl hygric acid, and the alkyl, ar