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Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging

✍ Scribed by Matthias M. Herth; Hanne D. Hansen; Anders Ettrup; Agnete Dyssegaard; Szabolcs Lehel; Jesper Kristensen; Gitte M. Knudsen


Book ID
116318463
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
771 KB
Volume
20
Category
Article
ISSN
0968-0896

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The novel 2-mercaptoimidazole derivatives, 1-[4-((2-methoxyphenyl)-1-piperazinyl)butyl]-2-mercaptoimidazole (3) and methyl[4-((2-methoxyphenyl)-1-piperazinyl))butyl] (2-mercapto-1-methylimidazol-5-yl)methanamide ( 8), were efficiently labelled with 11 C through methylation of the thioketone function