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Synthesis and estrogenic activities of novel 7-thiosubstituted estratriene derivatives

✍ Scribed by Chris P. Miller; Ivo Jirkovsky; Bach D. Tran; Heather A. Harris; Robert A. Moran; Barry S. Komm

Book ID
104364931
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
144 KB
Volume
10
Category
Article
ISSN
0960-894X

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✦ Synopsis

AbstractÐA diastereomerically pure series of 7a-thioestratrienes was prepared and evaluated for its anity for both the human estrogen receptor a and the more recently discovered estrogen receptor b. The functional estrogenic activities of the compounds were measured in a MCF-7 ERE-tk-luciferase assay. The activities and selectivities of the compounds were sensitive to the nature of the thioether side chain.

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