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Synthesis and Drug-Delivery Behavior of Chitosan-Functionalized Graphene Oxide Hybrid Nanosheets

✍ Scribed by Vijay Kumar Rana; Myeon-Cheon Choi; Jin-Yeon Kong; Gwang Yeon Kim; Mi Ju Kim; Sun-Hee Kim; Satyendra Mishra; Raj Pal Singh; Chang-Sik Ha

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
716 KB
Volume
296
Category
Article
ISSN
1438-7492

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✦ Synopsis

Abstract

Chitosan‐functionalized graphene oxides (FGOCs) were successfully synthesized. FGOCs were found to significantly improve the solubility of the GO in aqueous acidic media. The presence of organic groups was confirmed by means of XPS and TGA. Restoration of the sp^2^ carbon network and exfoliation of graphene sheets were confirmed by Raman spectroscopy, UV‐visible spectroscopy and WAXD. The SEM and AFM investigations of the resultant FGOCs showed that most of the graphene sheets were individual and few were layered. Controlled release behavior of Ibuprofen and 5‐fluorouracil was then investigated. We found that FGOCs are a promising new material for biological and medical applications.
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