✦ LIBER ✦

Synthesis and DNA-binding properties of 1,10-phenanthroline analogues as intercalating-crosslinkers

✍ Scribed by Toshinori Higashi; Keiko Inami; Masataka Mochizuki

Publisher: Journal of Heterocyclic Chemistry
Year: 2008
Tongue: English
Weight: 425 KB
Volume: 45
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570450654

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✦ Synopsis

Abstract

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We synthesized a series of bis(bromomethyl)‐1,10‐phenanthrolines as novel anticancer lead compounds and examined their DNA‐binding properties. 5,6‐Bis(bromomethyl)‐1,10‐phenanthroline showed DNA intercalating activity and DNA crosslinking activity, furthermore it is stable in aqueous solution.

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