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Synthesis and development of new 2-substituted 1-[3-(4-arylpiperazin-1-yl)propyl]-pyrrolidin-2-one derivatives with antiarrhythmic, hypotensive, and α-adrenolytic activity

✍ Scribed by Barbara Malawska; Katarzyna Kulig; Annika Gippert; Barbara Filipek; Jacek Sapa; Dorota Maciąg


Book ID
113619877
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
314 KB
Volume
60
Category
Article
ISSN
0014-827X

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Estimation of phospholipophilicity of 1-
✍ Katarzyna Kulig; Barbara Malawska 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB

A molecule library containing 42 1-[3-(arylpiperazin-1-yl)-propyl]-pyrrolidin-2-one derivatives has been designed and synthesized. The phospholipophilicity of the obtained compounds has been determined using immobilized artificial membrane high-performance liquid chromatography (IAM-HPLC). The perfo