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Synthesis and derivatization of a versatile α-substituted lactam dipeptide isostere

✍ Scribed by John J. Acton III; A.Brian Jones

Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
196 KB
Volume
37
Category
Article
ISSN
0040-4039

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📜 SIMILAR VOLUMES

Amino-alcohol dipeptide analogues: A sim
Amino-alcohol dipeptide analogues: A simple synthesis of a versatile isostere for the development of proteinase inhibitors
✍ R.J. Arrowsmith; D.E Davies; Y.C. Fogden; C.J. Harris; C. Thompson 📂 Article 📅 1987 🏛 Elsevier Science 🌐 French ⚖ 155 KB

Two sample approaches to an ammo-alcohol isostere of proteolytrcally-cleavable dipeptrde sequences are descrrbed; this isostere is incorporated into stereochemically-defined tetrapeptlde analogues. We1 and others2 have shown that replacement of the cleavable amrde bond of appropriate peptide substra