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Synthesis and Cytotoxicity of Substituted Ethyl 2-Phenacyl-3-phenylpyrrole-4-carboxylates

โœ Scribed by Michael A. Evans; Daniel C. Smith; Justin M. Holub; Anthony Argenti; Mafoloe Hoff; Gerard A. Dalglish; Donna L. Wilson; Brett M. Taylor; Joshua D. Berkowitz; Bruce S. Burnham; Keith Krumpe; John T. Gupton; Tanya C. Scarlett; Richard W. Durham; Jr; Iris H. Hall


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
214 KB
Volume
336
Category
Article
ISSN
0365-6233

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โœ Bruce S. Burnham; John T. Gupton; Keith Krumpe; T. Webb; Jordan Shuford; Brook B ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 67 KB

Two alkyl-3,4-bis(4-methoxyphenyl)pyrrole-2-carboxylates proved to be potent cytotoxic agents in the murine L1210 lymphoid leukemia screen. DNA synthesis was preferentially inhibited with the major target of the agents being de novo purine biosynthesis at the regulatory enzyme sites of PRPP-amido tr