Synthesis and cytotoxicity of nitrogen mustard/tripolypyrrole conjugate

✍ Scribed by Cun-Jiang Liu; Yan-Hong Liu; Li-Feng Cao; Yong Ye; Yu-Fen Zhao

• Book ID: 102342374
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2008
• Tongue: English
• Weight: 154 KB
• Volume: 45
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570450647

✦ Synopsis

Abstract

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A series of nitrogen mustard derivatives were synthesized by chloroform reaction and coupling reaction using DCC/ HOBT as promoting additives. The structure of compound was confirmed by ^1^H NMR, ^31^P NMR, MS and IR. The data show that the nitrogen mustard with tripolypyrrole as the linker inhibits all the four tested cells and has the highest activity.