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Synthesis and Cytotoxicity of Methyl-4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-dione Derivatives

✍ Scribed by Yu-Hua Chao; Sheng-Chu Kuo; Kelvin Ku; I-Ping Chiu; Chun-Hsiung Wu; Anthony Mauger; Hui-Kang Wang; Kuo-Hsiung Lee

Book ID
108480693
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
181 KB
Volume
7
Category
Article
ISSN
0968-0896

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2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-dione (BTP-11) enhances the ATRA-induced differentiation in human leukemia HL-60 cells
✍ Chun-Jen Chen; Yen-Fang Wen; Pi-Tsan Huang; Mei-Hua Hsu; Kuo-Hsiung Lee; Mei-Hwa 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 734 KB

a b s t r a c t 2-(1-Hydroxethyl)-4,8-dihydrobenzo [1,2-b:5,4-b ]dithiophene-4,8-dione (BTP-11) is a potent enhancer for all-trans retinoic acid (ATRA)-induced differentiation in HL-60 cells. Combination of BTP-11 and ATRA cut down the concentration of ATRA significantly, and that BTP-11 promoted th