Synthesis and cytotoxicity of 5-deazaflavins containing o- and p-quinone moieties

✍ Scribed by Tetsutaro Kimachi; Ken-ichi Sugita; Yoshinori Tamura; Miyuki Kagawa; Kumi Yamasaki; Fumio Yoneda; Takuma Sasaki

• Book ID: 104364912
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 178 KB
• Volume: 7
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(97)00100-5

✦ Synopsis

A series of 5-deazaflavo-10,11-quinones having o-quinone structure in the molecule were synthesized. The cytotoxicity of 5-deazaflavo-6,9-quinones (p-quinone derivatives) and 5-deazaflavo-10,11quinones (o-quinones) was evaluated in vitro against L1210 and KB cells. Some of the synthesized compounds exhibited cytotoxic activity comparable to that of mytomycin C.