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Synthesis and cytotoxic properties of a series of bicyclo[3.2.1]octane α-methylene ketones

✍ Scribed by J.A Miller; G.M Ullah; G.M Welsh; P Mallon

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
78 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

The 8-chlorobicyclo[3.2.1]oct-6-ene 3 has been prepared by a [3+2] cycloaddition route, and converted to the bicyclic a-methylene ketones 6 and 8-12, some of which showed cytotoxic properties.

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✍ J. A. de Groot; J. H. Koek; J. Lugtenburg 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 423 KB

## Abstract 1,1′‐methylene‐2,2′‐dipyrrolyl ketone can be conveniently prepared in high yield, starting from pyrrole, in three steps. It shows extreme properties that are not observed in comparable rigid ketone systems. These chemical and physical properties can be explained assuming mesomeric forms