𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and Cytotoxic Evaluation of Novel Dimethyl [1,1′-Biphenyl]-2,2′-dicarboxylates Bearing 1,3,4-Thiadiazole Moieties

✍ Scribed by Xiang-Wen Kong; Yi-Hua Zhang; Tao Wang; Yi-Sheng Lai; Si-Xun Peng

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
193 KB
Volume
5
Category
Article
ISSN
1612-1872

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In search of novel anticancer agents, two series of dimethyl [1,1′‐biphenyl]‐2,2′‐dicarboxylate derivatives, 8a–8k and 9a–9k, containing both methylenedioxy and 1,3,4‐thiadiazole moieties were designed and synthesized. Cytotoxicity of these compounds was evaluated in vitro against five human tumor cell lines, i.e., HepG2, KB, A549, K562, and MCF‐7. The results indicated that 8h, 8j, 8k, 9d, 9g, 9h, 9j, and 9k showed notable anticancer activities comparable to or stronger than that of 5‐fluorouracil, a canonical anticancer drug. Structure–activity relationships were also discussed based on the experimental data obtained.

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis, Antimicr
ChemInform Abstract: Synthesis, Antimicrobial and Cytotoxic Activities of 1,3,4-Oxadiazoles, 1,3,4-Thiadiazoles and 1,2,4-Triazoles.
✍ V. Padmavathi; G. Sudhakar Reddy; A. Padmaja; P. Kondaiah; Ali-Shazia Ali-Shazia 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 23 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v