Synthesis and cytotoxic activity of aziridinyl-1,4-naphthoquinones and naphthazarins
โ Scribed by Barbara Horowska; Zofia Mazerska; Andrzej Ledochowski; Gloria Cristalli; Palmarisa Franchetti; Sante Martelli
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 553 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0223-5234
No coin nor oath required. For personal study only.
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Using the human hepatoma cell line, HepG2, and the BALB/c mouse fibroblast cell line, 3T3, as the bioindicators in the neutral red cytotoxicity assay, the effect of hydroxyl substitution on the toxicity of 1,4naphthoquinone was studied. The sequence of potency for the quinones was 5,8-dihydroxy-1,4-
6-(1-Acyloxyalkyl)-5,8-dimethoxy-1,4-naphthoquinone (DMNQ; 5,8-dimethoxy-1,4-naphthoquinone) derivatives were synthesized and examined for their inhibitory effect on DNA topoisomerase-I (Topo I) and their antiproliferative activity against L1210 cells. The Topo-I inhibitory effect of 6-(1-hydroxyalk