✦ LIBER ✦
Synthesis and cyclodimerization of stable 1-t-alkylamino-2,3- epoxypropanes; related sterically promoted eight-membered ring closures
✍ Scribed by V.R. Gaertner
- Publisher
- Elsevier Science
- Year
- 1964
- Tongue
- French
- Weight
- 311 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
We wish to describe exceptionally stable new secondary amino epox%des, their cyclodimerization to diazacyclo&tanediols, and novel related eight-membered ring closures wNch may be generally useful.
Although several adequately characterized secondary amino epoxides have been described (l), none was appreciably stable under ambient conditions. Equlmolar reaction of t-alkylamines with epichlorohydrin' (2), either reactant being present in 2%lOO.% excess in methanol at 2G-25'C, followed by expeditious isolation and dehydrohalogena-