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Synthesis and cvs activity of 1-(2,3, 2,5, 2,6 Dichlorophenyl)-3-MorpholinophenyL-5-Substituted benzylidine-thiobarbituric acids (3–17)

✍ Scribed by SINGH, A; MISRA, V


Book ID
122094032
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
216 KB
Volume
21
Category
Article
ISSN
1043-6618

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Synthesis of 5-(functionalized acyl)-1,3
✍ Hanafi H. Zoorob; Mohamed A. Ismail; Lucjan Strekowski 📂 Article 📅 2001 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 53 KB

## Abstract A sodium derivative of 1,3‐dimefhylbarbituric acid or 1,3‐diethyl‐2‐thiobarbituric acid undergoes an efficient monoacylation at C5 by the reaction with ω‐chloroalkanoyl chloride or diacid dichloride in the presence of pyridine in tetrahydrofuran. A nucleophilic displacement of the chlor