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Synthesis and crystal structure of 5-pyrazol-4,5-dihydropyrazoles derivatives

✍ Scribed by Zhengfeng Xie; Xuexia Mo; Gang Liu; Fangming Liu

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
482 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

magnified image

A series of 1‐acetyl(or phenyl)‐3‐aryl‐5‐(1‐phenyl‐3‐methyl‐5‐aryloxyl‐pyrazol)‐4,5‐dihydropyrazole derivatives have been efficiently synthesized under refluxing in glacial acetic acid with two kinds of hydrazines and five kinds of chalcones of 1‐phenyl‐methyl‐5‐phenoxyl‐pyrazol‐4‐aldehyde. The structures were confirmed on the basis of ^1^H NMR, IR, MS and element analysis, and the crystal structure of the compound 4c was determined by single crystal X‐ray diffraction. The compound 4c belongs to monoclinic system with space group P2(1)/n, a = 11.8779(3) nm, b = 12.0901(2) nm, c = 17.7004(4) nm, α = 90°, β = 100.05(10)°, γ = 90°, Formula weight: 549.46, Triclinic V = 2502.89(9) nm^3^, D~c~ = 1.458 Mg/m^3^, Z = 4, F (000) = 1128.

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