✦ LIBER ✦
Synthesis and Conformational Studies of a Hybrid Cyclic Peptide Based on cis-β-Furanoid Sugar Amino Acid (FSAA) and Ornithine
✍ Scribed by Srivari Chandrasekhar; Birudaraju Saritha; Police Naresh; Marelli Udayakiran; Chada Raji Reddy; Bharatam Jagadeesh
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- German
- Weight
- 327 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
The conformational control of a 14‐helix nucleating template, cis‐β‐furanoid sugar amino acid (FSAA), over a flexible δ‐amino acid, ornithine is studied in a FSAA‐ornithine cyclic tetrapeptide. Extensive NMR and MD studies reveal that the cyclic peptide adopts a three‐dimentional bowl‐shape cavity, which promotes six‐ and seven‐membered intra‐ and inter‐residue H‐bonding, in polar and non‐polar solvents, respectively.