✦ LIBER ✦
Synthesis, and conformational and biological study of 2-D-Ala,5-des-Met-enkephalin hydrazide modified at the carboxylic end by poly-N-vinylimidazole
✍ Scribed by G. Vlasov; E. Krasnikova; N. Kozhevnikova; N. Illarionova; I. Denisov
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1987
- Tongue
- English
- Weight
- 535 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0006-3525
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✦ Synopsis
Synopsis
N, N-bis-2-~-Ala,5-des-Met-enkephalin hydrazide of azo-isobutyric acid was synthesized. This was used to obtain polyvinylimidazole derivatives of an enkephalin analog, modified at the carboxylic end by poly-N-vinylimidazole. The effect of modification of tetrapeptide hydrazide on its conformational properties and biological activity in viw and in vitro was studied.
*This paper is dedicated to the 70th anniversary of Professor G. Maneke.