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Synthesis and Conformational Analysis of Macrocycles Related to 10-Oxa-epothilone

✍ Scribed by Delphine Quintard; Philippe Bertrand; Christian Bachmann; Jean-Pierre Gesson

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 209 KB
Volume: 2004
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.200400212

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✦ Synopsis

Abstract

A short and convergent synthesis of macrocyclic lactones related to 10‐oxa‐epothilone is based on aldolisation of a 3‐(2′‐methylallyloxy) aldehyde derived from methyl (2__S__)‐3‐hydroxy‐2‐methylpropionate followed by ring‐closing metathesis. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

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