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Synthesis and Chemistry of Enaminones

✍ Scribed by Khadijah M. Al-Zaydi; Layla M. Nhari


Publisher
John Wiley and Sons
Year
2006
Weight
8 KB
Volume
37
Category
Article
ISSN
0931-7597

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The 3-anilinoenones 3a,b were prepared from the corresponding 3-dimethyl-aminopropenones. The reactivity of 3a,b towards a variety of carbon and nitrogen nucleophiles as well as naphthoquinones is reported.

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## Abstract Reacting 1,3‐diphenyl‐propan‐2‐one with equimolecular amount of dimethylformamide dimethylacetal afforded the enaminone **4.** This when reacted with another equimolecular amount of dimethylformamide dimethylacetal afforded the dienaminone **5.** Compound **4** condenses with cyanothioa

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## Abstract 1‐Substituted‐3‐dimethylaminopropenones **1a‐d** reacted with acetylacetone and with ethyl acetoacetate to yield regioselectively 2,3,6‐trisubstituted pyridines. Refluxing **1a‐d** in acetic acid/ammonium acetate resulted in the formation of 6‐substituted‐3‐aroylpyridines, whereas reflu

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## Abstract Twelve new 7‐aryl‐3‐cyanopyrazolo[1,5‐__a__]pyrimidines (**3a‐f**) and ethyl 7‐arylpyrazolo[1,5‐__a__]pyrimidine‐3‐carboxylates (**3g‐l**) have been conveniently synthesized by the reaction of enaminones with 5‐amino‐1__H__‐pyrazoles in good yields under microwave irradiation. With one