Synthesis and chemiluminescence of 1,3-disubstituted pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyridazine-5,8(6h,7h)-diones and related compounds
✍ Scribed by Yoshinori Tominaga; Noriko Yoshioka; Seigo Kataoka; Norihito Aoyama; Toshiyuki Masunari; Akira Miike
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 249 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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An improved synthesis of 3-(substituted)pyrimido[4,5-c]pyridazine-5,7(1H,6H)-diones, a known subclass of 4-deazatoxoflavins, is reported. The approach involves treatment of 3-methyl-6-(1-methylhydrazinyl)uracil with representative phenyl and alkyl glyoxal monohydrates, which in turn are obtained by
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## Abstract magnified image The synthetic utility of 1,3‐dipolar cycloaddition of DMAD to sydnones has been exploited in the preparation of new 1‐aryl‐4,5‐dihydro‐1__H__‐pyrazolo[3,4‐__d__]pyridazine‐3,6‐diones **7a‐j** and their aromatic 3,6‐dichloro analogues **8a‐j**. The lactam‐lactim tautomer
I211 Genbve 4 (5. V .86) ~ Comparative results on the reduction of 4,6,7,8-tetrahydro-7,7-dimethyl-2H-1 -benzopyran-2,5(3H)-diones 1 are reported. Hydride reduction (LiAIH, in EtzO or NaBH, in i-PrOH) affords 2,3,4,6,7,8-hexahydro-5H-l-benzopyran-5-ones 5 in 30-60 % isolated yield. Photochemical red