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Synthesis and characterization of the 5-methyl-2′-deoxycytidine glycol–dioxoosmium–bipyridine ternary complex in DNA

✍ Scribed by Umemoto, Tadashi ;Okamoto, Akimitsu

Book ID: 118045271
Publisher: Royal Society of Chemistry
Year: 2008
Tongue: English
Weight: 140 KB
Volume: 6
Category: Article
ISSN: 1477-0520
DOI: 10.1039/b716400a

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## ABSTRACT To investigate the changes in the levels of DNA methylation in the testis during development after neonatal transient exposure to DNA methyltransferase (DNMT) inhibitors, we orally administered Sprague–Dawley (SD) rats with 5‐aza‐2′‐deoxycytidine (5‐aza‐CdR; 0.025 or 0.25 mg kg^−1^) or