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Synthesis and characterization of radiopaque magnetic core-shell nanoparticles for X-ray imaging applications

✍ Scribed by Anna Galperin; Shlomo Margel

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
334 KB
Volume
83B
Category
Article
ISSN
1552-4973

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✦ Synopsis

Abstract

Radiopaque magnetic γ‐Fe~2~O~3~/poly(2‐methacryloyloxyethyl(2,3,5‐triiodobenzoate)) core‐shell nanoparticles of narrow size distribution were prepared by emulsion polymerization of the iodinated monomer 2‐methacryloyloxyethyl(2,3,5‐triiodobenzoate) in the presence of maghemite (γ‐Fe~2~O~3~ nanoparticles coated with a dextran shell are commonly used as contrast agents for magnetic resonance imaging (MRI). The present nanoparticles have similar core‐shell structure substituting the dextran for the iodo polymer. These core‐shell nanoparticles may therefore be useful as imaging contrast agents to detect various pathogenic zones and to observe different disease states in both modes: X‐ray and MRI. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007

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