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Synthesis and characterization of poly(2-ethyl 2-oxazoline)-conjugates with proteins and drugs: Suitable alternatives to PEG-conjugates?

✍ Scribed by Anna Mero; Gianfranco Pasut; Lisa Dalla Via; Martin W.M. Fijten; Ulrich S. Schubert; Richard Hoogenboom; Francesco M. Veronese


Book ID
113691659
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
398 KB
Volume
125
Category
Article
ISSN
0168-3659

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## Abstract Trastuzumab (TRZ) is a humanized monoclonal antibody that targets the extracellular domain of the human epidermal growth factor receptor type 2 (Her2). Semitelechelic (ST) poly[__N__‐(2‐hydroxypropyl)methacrylamide]–TRZ conjugates are successfully synthesized and evaluated as a potentia