Synthesis and characterization of photo-crosslinkable hydrogel membranes based on modified chitosan

✍ Scribed by M. Monier; Y. Wei; A.A. Sarhan; D.M. Ayad

• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 789 KB
• Volume: 51
• Category: Article
• ISSN: 0032-3861
• DOI: 10.1016/j.polymer.2010.01.001

✦ Synopsis

In order to develop a non toxic and biocompatible hydrogel system with potential ability in biotechnology, modified photo-crosslinkable hydrogel membranes based on chitosan were prepared. Using an EDC/NHS conjugation method, chitosan was chemically modified to incorporate a photosensitive a-cyano-4hydroxycinnamic acid moiety with various degrees of substitutions. Fourier transform infrared spectra (FTIR), proton nuclear magnetic resonance ( 1 H NMR) and ultraviolet-visible light spectra (UV-vis) were used for structural characterization of modified chitosan, The obtained membranes were crosslinked by irradiation in the ultraviolet region, where the photosensitive monomers showed maximum sensitivity. The prepared photo-crosslinked hydrogel membranes were investigated by thermal gravimetric analysis (TGA) and wide angle X-ray diffraction (WAXD). The swelling behaviors were investigated in terms of pH, time of swelling, and degree of substitution. Also, mechanical properties of the different photo-crosslinked hydrogel membranes were studied in both dry and wet conditions.