Abstrack me tkst synthf!aii and optical activity measurement of homocbii. monodisperse &ndrimcrs is reported Optically active @R. MhatWic acid is used to construct the zero and fust-generatioo optically acti% homocbirai dcndrimcrs 1 sod 2 in good yields. The relatkmsbip between the optical mtaticm of all these molecules end the number of chii tartark acid units resided in them is explomd.
Dendrimer macromolecules an? highly branched polymers with a dendtitic. tmelike structum and defined thre&imensional morphologyt. This type of polymer has found potential applications as novel materials for engineering plastics2, molecular devices3, and biological mimics * % 4. Since the publication of the review article by Tomalia*a. new types of dendrimers with different branching skeletons, connectivity units and novel topological structures have been tepotteds. Apart from several reports6 describing tbe use of biomoleeules such as nucleotid~ or amino acids as building blocks for the construction chiral nucleic acid or peptide dendrimers, no other optically active, homochiral dendrimer has ever been disclosed. However, these papers put most emphasis on tbe automated synthesis and the biological roles of these biopolymers rather than on their chin&y nature. In fact., no optical activity and spectroscopic data was reported for any of these compounds in these papers. We am