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Synthesis and characterization of new phthalhydrazothiazole derivatives: A preliminary investigation on their activity against hepatocellular carcinoma

✍ Scribed by Maria Cristina Cardia; Simona Distinto; Elias Maccioni; Antonio Plumitallo; Laura Sanna; Maria Luisa Sanna; Sara Vigo

Book ID: 102341058
Publisher: Journal of Heterocyclic Chemistry
Year: 2009
Tongue: English
Weight: 221 KB
Volume: 46
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.138

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✦ Synopsis

Abstract

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The synthesis of new 2‐(4‐substituted thiazol‐2‐yl)‐2,3‐dihydrophthalazine‐1,4‐diones, 2‐(4‐oxo‐4,5‐dihydro‐thiazol‐2‐yl)‐2,3‐dihydrophthalazine‐1,4‐diones, and 2‐(5‐arylidene‐4‐oxo‐4,5‐dihydrothiazol‐2‐yl)‐2,3‐dihy‐drophthalazine‐1,4‐diones is reported. The introduction of different substituents on the phthalazine, the thiazole and the thiazolinone has been studied. The new compounds have been characterized and evaluated for their antiproliferative activity against hepatocellular carcinoma, one of the most lethal tumors. The activity shown by some of these compounds towards liver tumor cells is encouraging. J. Heterocyclic Chem. (2009).

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