Synthesis and characterization of new hydrogels on the basis of water-soluble maleic anhydride copolymers with γ-aminopropyltriethoxysilane

Oligonucleotide synthesis on maleic anhy

Oligonucleotide synthesis on maleic anhydride copolymers covalently bound to silica spherical support and characterization of the obtained conjugates

✍ Carole Chaix; Claire Minard-Basquin; Thierry Delair; Christian Pichot; Bernard M 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 247 KB 👁 1 views

A new route was proposed to make polymer-oligonucleotide conjugates of potential applications in diagnostics. It consisted in direct synthesis of oligonucleotides onto controlled pore glass surface grafted with poly(maleic anhydride-alt-methyl vinyl ether) (P[MAMVE]) or poly(maleic anhydride-alt-eth