Synthesis and characterization of new biodegradable fluorescing poly(amide-anhydrides)

✍ Scribed by H L Jiang; K J Zhu; L J Dai

• Book ID: 104528789
• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 136 KB
• Volume: 50
• Category: Article
• ISSN: 0959-8103
• DOI: 10.1002/pi.693

✦ Synopsis

Abstract

Biodegradable/alternate/poly(amide‐anhydrides), [C(O)PhNHC(O)(CH~2~)~n~C(O)O]~x~, were synthesized by melt polycondensation, where n was 2, 3 or 4. The polymers have been characterized by NMR, DSC, wide‐angle X‐ray diffractometry and fluorometry. All the polymers are amorphous and their T~g~ ranges from 60 to 80 °C. Poly(p‐(carboxyethylformamido)benzoic anhydride) (PCEFB) as a film or in solution in chloroform can emit strong fluorescence, which was not observed for the other two polyanhydrides (n  = 3, 4). The maximum emission wavelength varies with the excitation wavelength, 480 and 520 nm at the excitation wavelength of 470 nm, and 430 nm at 356 nm. In addition, the fluorescence intensities increase linearly with the molecular weight of PCEFB. Such inherent fluorescing properties of PCEFB, together with its biodegradability, make the polymer a potential visible matrix for drug delivery.

© 2001 Society of Chemical Industry