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Synthesis and Characterization of New Binaphthyl-Linked Phenanthroline-, Bipyridine-, or Pyridine-Derived Ligands, and the Study of Their Cytotoxic Activity

✍ Scribed by Nesrin Beynek; Gühergül Uluçam; Kadriye Benkli; Ays̨e Tansu Koparal

Publisher
John Wiley and Sons
Year
2008
Tongue
German
Weight
203 KB
Volume
91
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

In the present work, we describe the synthesis and characterization of five new versatile acyclic or macrocyclic ligands containing binaphthyl‐linked pyridine, bipyridine, or phenanthroline groups in their framework (see Schemes 1–4). The structures of the ligands were elucidated on the basis of elemental analyses, IR, ^1^H‐NMR, ^13^C‐NMR, and FAB mass spectra. The cytotoxicity of these compounds was tested in vitro by using the tetrazolium salt reduction (MTT) assay on A549 (human lung carcinoma epithelial like) cells. All of the tested compounds induced time‐ and concentration‐dependent cytotoxic effect.

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The Synthesis and Characterization of New Optically Active ‘dimeric’ ‘pineno’-[4,5]-fused 2,2′-bipyridines linked without spacer or by small spacer groups
✍ Nicholas C. Fletcher; F. Richard Keene; Marco Ziegler; Helen Stoeckli-Evans; Hei 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 German ⚖ 657 KB

## Abstract Linked chiral bipyridines 2–4 are prepared by combining two optically active ‘pineno’‐[4,5]‐fused 2,2′‐bipyridines in a stereoselective reaction (__Scheme 1__). These potential ligands are new members of the ‘chiragen’ family, and are characterized by NMR spectroscopy and, in the case o