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Synthesis and Characterization of Iodinated Tetrahydroquinolines Targeting the G Protein-Coupled Estrogen Receptor GPR30

✍ Scribed by Ramesh, Chinnasamy; Nayak, Tapan K.; Burai, Ritwik; Dennis, Megan K.; Hathaway, Helen J.; Sklar, Larry A.; Prossnitz, Eric R.; Arterburn, Jeffrey B.

Book ID: 121478022
Publisher: American Chemical Society
Year: 2010
Tongue: English
Weight: 925 KB
Volume: 53
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm9011802

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## Abstract Lewis acid‐catalyzed aza‐Diels—Alder cycloaddition of an aniline derivative (I) with cyclopentadiene (II) and various aromatic bromides (III) can be carried out in a three‐component process or by two‐step method to afford GPR30‐selective antagonist G‐1 (IVa) and derivatives (IV), (VI)/(