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Synthesis and characterization of diorganotin(IV) complexes of N-(2-pyridylmethylene)arylamines and mutagenicity testing in vivo of Et2SnCl2·[L4=N-(2-pyridylmethylene)-4-toluidine]

✍ Scribed by Swarnali Basu Baul; Tushar S. Basu Baul; Eleonora Rivarola; Dainis Dakternieks; Edward R. T. Tiekink; Christine Syng-ai; Anupam Chatterjee

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
106 KB
Volume
12
Category
Article
ISSN
0268-2605

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✦ Synopsis

Diorganotin(IV) dichloride complexes of the type R 2 SnCl 2 ÁL (R = methyl, ethyl, vinyl, t-butyl, n-butyl or phenyl; L = N-(2-pyridylmethylene)arylamine) have been synthesized and characterized on the basis of IR, NMR and 119 Sn Mo ¨ssbauer studies. Investigation of the complexes indicated that N-(2-pyridylmethylene)arylamines form distorted trans-octahedral complexes with R 2 SnCl 2 similar to the wellknown R 2 SnCl 2 ÁL. Cytogenetic toxicology testing has been performed for Et 2 SnCl 2 ÁL 4 [L 4 = N-(2-pyridylmethylene)-4-toluidine] in mouse bone-marrow cells in vivo since such testing is a regulatory requirement before new drugs are released. This tin compound induced delay in cell-cycle kinetics and sister chromatid exchanges (SCEs) significantly. The effect of Et 2 SnCl 2 ÁL 4 was greater when endogenous glutathione (GSH) was depleted by buthionine sulphoximine (BSO). It seems that Et 2 SnCl 2 ÁL 4 induces SCEs due to formation of adduct by binding on DNA which could interfere in DNA synthesis and cause delay in cell proliferation. Depletion of GSH could reduce the shielding effect of GSH on chromatin and allows more Et 2 SnCl 2 ÁL 4 to bind on DNA.

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