✦ LIBER ✦

Synthesis and characterization of chroman-containing compounds and their preliminary assessment of cytotoxicity toward two human cancer cell lines

✍ Scribed by Ying Tang; Jie Wei; Wei Zhong; Xiaoming Liu

Book ID: 102233768
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 219 KB
Volume: 21
Category: Article
ISSN: 1042-7163
DOI: 10.1002/hc.20621

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✦ Synopsis

Abstract

A series of chroman derivatives were synthesized by employing o‐methyl phenol as a precursor. These compounds were fully characterized using IR, NMR spectroscopic techniques, and elemental analysis. Mechanisms for the formation of the chroman moiety of these compounds were also proposed. MTT (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) assay was used to estimate their cytotoxicity toward two cancer cell lines: human ovarian cancer (A2780) and human cervical cancer (Hela). © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:423–429, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20621

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