Synthesis and characterization of chitosan-modified polymethyl methacrylate latex particles

✍ Scribed by Chorng-Shyan Chern; Cheng-Kang Lee; Chia-Che Ho

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 240 KB
• Volume: 37
• Category: Article
• ISSN: 0887-624X
• DOI: 10.1002/(sici)1099-0518(19990515)37:10<1489::aid-pola11>3.0.co;2-u

✦ Synopsis

Stable chitosan-modified polymethyl methacrylate (PMMA) latex particles were prepared by using 2,2Ј-azobis(2-amidinopropane) dihydrochloride (V-50) as the cationic initiator. The polymerization rate (R p ) is controlled by the V-50 concentration ([V-50]) and R p is less sensitive to the chitosan concentration ([C]) used in the synthesis work. The reaction system follows Smith-Ewart Case III kinetics due to the relatively large particles produced. The zeta potential data show that the isoelectric point (pI) of the latex particles is 10.7. The amounts of V-50 (C V-50 ) and chitosan (C c ) ultimately incorporated into the particles correlate reasonably well with [V-50] and [C], respectively. At pH 7, the quantity of the negatively charged bovine serum albumin (BSA, pI ϭ 4.8) adsorbed on the positively charged chitosan-free particles (Q) via the electrostatic interaction increases with increasing C V-50 . However, Q is relatively insensitive to changes in C c . This result implies that only the outermost region of the hairy chitosan-modified particles is available for adsorption of the relatively large protein species. Colloidal stability shows a significant influence on the BSA adsorption process.