Synthesis and Characterization of Atrop­isomers Arising from 1,3-Cyclohexanediones by Intermolecular Tandem-Michael/Michael Additions

✍ Scribed by Liliana E. Luna; Gustavo Seoane; Raquel M. Cravero

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 341 KB
• Volume: 2008
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.200700803

✦ Synopsis

Abstract

Intermolecular tandem‐Michael/Michael addition reactions of alkyne acceptors and CH‐acidic compounds such as 1,3‐cyclohexanedione (2a) and dimedone (2b) under L‐proline catalysis furnished four new products 1a–d with C~2~ axial chirality. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)