Synthesis and characterization of a technetium nitrido dimer

✍ Scribed by Terrence Nicholson; Daniel J Kramer; Alan Davison; Alun G Jones

• Book ID: 104138483
• Publisher: Elsevier Science
• Year: 2001
• Tongue: English
• Weight: 78 KB
• Volume: 316
• Category: Article
• ISSN: 0020-1693
• DOI: 10.1016/s0020-1693(01)00373-5

✦ Synopsis

In 1993, Baldas et al. [1]

reported the synthesis of the technetium(VI) nitridodi (m-oxo) dimer (AsPh 4 ) 2 [{TcNCl 2 } 2 (m-O) 2 ], which was synthesized from methanesulfonic acid and Cs 2 [TcNCl 5 ] in water with heating. We report here, the facile synthesis and characterization of the tetrabutylammonium analog, (

and water in acetone at room temperature. This may have important ramifications for technetium based radiopharmaceutical development, since [ 99m TcNCl 4 ] -is frequently employed at the tracer level as a technetium nitrido synthon, and technetium nitrido chemistry continues to be a rapidly developing area in radiopharmaceutical research [1].

The infrared spectrum of 1 displays a pronounced absorption at 1062 cm -1 , attributed to the Tc N bond. The FAB(-) mass spectrum displays the parent ion of 642 m/z which corresponds to {(Bu 4 N)[{TcNCl 2 } 2 (m-O) 2 ]} -. The X-ray crystal structure of 1 is similar to the previously reported tetraphenylarsonium analog [2]. The technetium nitrogen triple bond lengths are 1.601(7) and 1.597(7) A , . The X-ray structure solution for C 32 H 72 Cl 4 N 2 O 4 Tc of molecular weight 886.72 g mol -1 : Monoclinic space group P2 1 /n, a= 15.